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June 12, 2026Cancer BiomarkersOpen Access

The clinical assessment of miR-34a and miR-135b panel as promising diagnostic biomarkers predict the risk of colorectal cancer: A case-control study

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Authors

RKRoya KaramiENElaheh NajafiABAnahita Babaei

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Overview

Case-control study explores miRNA levels predicting colorectal cancer risk, suggesting diagnostic potential.

Key Points

  • This study aims to evaluate the expression levels of miR-34a and miR-135b as potential biomarkers for early colorectal cancer diagnosis.
  • Measured tissue and serum levels of miRNAs 34a and 135b in 15 pairs of colorectal cancer and normal tissue.
  • Assessed the predictive value using receiver operating characteristic curves.
  • Analyzed expression levels of target genes SIRT1 and DAPK-1.
  • miRNA-34a was significantly downregulated, while miRNA-135b was upregulated in CRC tissues compared to normal tissue.
  • Similar expression patterns were observed in serum from CRC patients versus non-CRC individuals.
  • SIRT1 levels increased and DAPK-1 levels decreased in CRC tissues compared to adjacent normal tissue.

Cite This Study

Karami et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba4a18101cf8926f02fd0https://doi.org/10.1177/18758592261429266
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