What question did this study set out to answer?

This study aims to formulate and evaluate dorzolamide hydrochloride-loaded solid lipid nanoparticles embedded in carbon nanotubes for glaucoma treatment.

June 10, 2026Drug Delivery Letters

Optimization of Novel Ocular Drug Delivery of Dorzolamide Hydrochloride for the Treatment of Glaucoma

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This study aims to formulate and evaluate dorzolamide hydrochloride-loaded solid lipid nanoparticles embedded in carbon nanotubes for glaucoma treatment.
Conducted a comparative evaluation of CNT-SLN formulations from different sources.
Employed response surface methodology utilizing a 23-factorial design for optimization.
Prepared and analyzed the CNT-SLN complex with various parameters including morphology and drug release.
SLNs were successfully coated onto CNT, confirming effective synthesis.
In vitro release exhibited a biphasic profile with an initial burst followed by sustained release, consistent with Fickian diffusion.
Formulations showed satisfactory drug entrapment and stability according to various evaluated parameters.

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Implication

Randomized trial evaluates dorzolamide hydrochloride delivery in glaucoma treatment, suggesting improved absorption method.

Cite This Study

Sakpal et al. (2026) studied this question.

synapsesocial.com/papers/6a28ff6a6f82f25be989c517 https://doi.org/10.2174/0122103031416667251210061242

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Optimization of Novel Ocular Drug Delivery of Dorzolamide Hydrochloride for the Treatment of Glaucoma

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Discussion

Implication

Cite This Study

Optimization of Novel Ocular Drug Delivery of Dorzolamide Hydrochloride for the Treatment of Glaucoma

Key Points

Discussion

Implication

Cite This Study

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