What does this research mean for the field?

Continuous glucose monitoring (CGM) metrics, including elevated mean glucose, increased glycemic variability, and reduced hypoglycemia, are significantly associated with impending diabetic ketoacidosis (DKA) events up to 89 days prior to hospitalization in adults with type 1 diabetes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess how continuous glucose monitoring metrics correlate with diabetic ketoacidosis events in adults with type 1 diabetes.

June 10, 2026Diabetes

1296-OR: Continuous Glucose Monitoring Metrics Are Associated with Diabetic Ketoacidosis across Pre-Event Time Windows

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To assess how continuous glucose monitoring metrics correlate with diabetic ketoacidosis events in adults with type 1 diabetes.
Examined adults with type 1 diabetes treated in a health system from 1/1/2017 - 3/20/2025.
Utilized CGM data from Dexcom Clarity and employed mixed-effects models to analyze CGM metrics versus non-DKA data.
Identified DKA events using ADA 2024 Consensus criteria, focusing on pre-DKA and matched non-DKA periods.
On the day prior to DKA, mean glucose was 263 mg/dL compared to 199 mg/dL one day prior to non-DKA (p<0.001).
The proportion of time glucose was >250 mg/dL increased to 50% before DKA compared to 24% in non-DKA (p<0.001).
Glycemic variability was elevated in the 7-day pre-DKA window (MAGE 180 vs. 157, p=0.006).

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Implication

Randomized trial finds links between continuous glucose monitoring metrics and diabetic ketoacidosis events in adults with type 1 diabetes, suggesting improved risk assessment methods.

Cite This Study

KOHLENBERG et al. (2026) studied this question.

synapsesocial.com/papers/6a28ff956f82f25be989c6dc https://doi.org/10.2337/db26-1296-or

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Implication

Randomized trial finds links between continuous glucose monitoring metrics and diabetic ketoacidosis events in adults with type 1 diabetes, suggesting improved risk assessment methods.

1296-OR: Continuous Glucose Monitoring Metrics Are Associated with Diabetic Ketoacidosis across Pre-Event Time Windows

Key Points

Discussion

Implication

Cite This Study

1296-OR: Continuous Glucose Monitoring Metrics Are Associated with Diabetic Ketoacidosis across Pre-Event Time Windows

Key Points

Discussion

Implication

Cite This Study

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