Randomized trial investigates combined effects of uric acid and retinol-binding protein 4 on insulin resistance in type 2 diabetes, suggesting better evaluation methods.
Key Points
This study aims to identify risk factors for insulin resistance in type 2 diabetes and examine the relationship between uric acid and retinol-binding protein 4.
Included 570 type 2 diabetes patients aged 18-60 from Taizhou Hospital.
Performed univariate and multivariate logistic regression to assess associations between uric acid, RBP4, and insulin resistance risk.
Conducted mediation analysis to investigate the role of RBP4 and utilized ROC curve analysis for model evaluation.
RBP4 and uric acid levels were significantly correlated with HOMA-IR (p < 0.01).
RBP4 partially mediated the relationship between uric acid and insulin resistance (p < 0.05, mediating effect 23.2%).
The combination of RBP4 and uric acid was more effective for detecting insulin resistance than either alone (AUC = 0.788, p < 0.001).