Nonfamilial Pseudoxanthoma Elasticum: A Case Report With Review of Selected Literature

A 44‐year‐old woman with classic cutaneous manifestations of nonfamilial PXE presented with multiple 3 to 10 mm yellowish papules coalescing into well‐demarcated, cobblestone‐like plaques. Previous ophthalmologic evaluation revealed retinal angioid streaks, while no cardiovascular involvement was reported. PXE is a rare multisystem disorder associated with significant morbidity, requiring a multidisciplinary approach to optimize patient outcomes and quality of life. Cutaneous involvement usually represents the initial manifestation of the disease; therefore, accurate recognition of these lesions may facilitate prompt diagnosis and prevent further complications. Advances in the understanding of the underlying molecular pathways open the possibility for the development of novel therapeutic strategies, which may improve patient prognosis and potentially modify the natural history of the disease.