Psychological and behavioral mechanisms linking childhood trauma profiles to voice-related distress in schizophrenia spectrum disorders: latent class, mediation, and conditional process analyses

Mads Juul Christensen; A. SCHOU OLESEN; Thomas Ward; Amy Hardy; Jan Mainz; Neil Thomas; Lisa Charlotte Smith; Lise Mariegaard; Merete Nordentoft; Louise Birkedal Glenthøj; Ditte Lammers Vernal

doi:10.1017/s0033291726104437

January 1, 2026Psychological MedicineOpen Access

Psychological and behavioral mechanisms linking childhood trauma profiles to voice-related distress in schizophrenia spectrum disorders: latent class, mediation, and conditional process analyses

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Key Points

This study aims to explore how different childhood trauma profiles impact voice-related distress in individuals with schizophrenia spectrum disorders, considering psychological mechanisms.
Cross-sectional design involving 266 participants with schizophrenia-spectrum diagnoses.
Childhood trauma profiles derived through latent class analysis of Childhood Trauma Questionnaire scores.
Structural equation modeling was used to analyze mediation effects, with gender as a moderator.
Significant differences in indirect effects were found for persecutory beliefs about voices (1 < 3), voice power (1 < 3), and sleep disturbances (1 < 2).
Age adjustment revealed a difference in the indirect effect of negative self-beliefs (1 < 3).
No significant gender moderation was identified.

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Implication

Cross-sectional study examines psychological mediation in voice-related distress linked to childhood trauma in schizophrenia patients, indicating therapeutic implications.

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Cite This Study

Christensen et al. (2026) studied this question.

synapsesocial.com/papers/6a28ffc76f82f25be989ca0e https://doi.org/10.1017/s0033291726104437

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Psychological and behavioral mechanisms linking childhood trauma profiles to voice-related distress in schizophrenia spectrum disorders: latent class, mediation, and conditional process analyses

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Psychological and behavioral mechanisms linking childhood trauma profiles to voice-related distress in schizophrenia spectrum disorders: latent class, mediation, and conditional process analyses

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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