Key result
Dyslipidemia is linked to lower physical quality-of-life scores in adults with systemic lupus erythematosus.
Cohort (n=169)
No
Odds Ratio: 0.986 (95% CI 0.972–1)
p-value: p=0.0446
Dyslipidemia is common in SLE patients and is associated with poorer patient-reported physical quality of life, highlighting the need for cardiovascular risk management.
Background: Systemic lupus erythematosus (SLE) is associated with an increased burden of cardiovascular disease (CVD), driven by dyslipidemia, hypertension, obesity, inflammation, and treatment. These factors can impact patient quality of life (QoL) by limiting physical activity. Objectives: To characterize lipid abnormalities as CVD risk factors in a Saudi SLE cohort and assess associations between lipid profile, SLE features, treatment, and patient-reported outcomes of physical activity. Methods: A cohort of adult SLE patients followed at King Saud University Medical City since 2021 was analyzed. Demographics, lipid profiles, blood pressure, BMI, SLEDAI-2K, SDI, disease duration, and treatment data were collected. Physical function and quality of life were assessed using the LupusQoL and PROMIS Physical Function T scores. Univariate and multivariate logistic regression analyses were conducted to identify associations between lipid abnormalities, SLE-related factors, and QoL physical activity measures. Results: A cohort of 169 patients (88.2% female, mean age 39.3 ± 12.4 years) was evaluated to assess the presence of dyslipidemia (23.7%), obesity (BMI ≥ 25, 66.3%), and hypertension (≥130/80 mmHg, 26.0%). Mean SLE duration was 9.2 ± 7.7 years and mean SLEDAI-2K was 11.0 ± 7.0. Among these patients, 52.7% used steroids, 88.2% used antimalarial drugs, and 53.8% used immunosuppressives. Dyslipidemia was associated with lower LupusQoL physical scores (adjusted OR 0.986; 95% CI 0.972–1.000; p = 0.0446). No significant associations were found between lipid levels and the PROMIS Physical Function T score. Conclusions: In this Saudi SLE cohort, dyslipidemia and other modifiable CVD risks were common. Dyslipidemia correlated with poorer LupusQoL-specific physical scores, which highlights the importance of lifestyle changes in patients with SLE.
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Almaghlouth et al. (2026) conducted a cohort in Systemic lupus erythematosus (SLE) (n=169). Dyslipidemia vs. Absence of dyslipidemia was evaluated on LupusQoL physical scores (adjusted OR 0.986, 95% CI 0.972-1.000, p=0.0446). Dyslipidemia was significantly associated with lower LupusQoL physical scores in adult patients with systemic lupus erythematosus (adjusted OR 0.986; 95% CI 0.972-1.000; p=0.0446).
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