Randomized trial evaluates barriers and nursing interventions to improve medication adherence in children with epilepsy, suggesting a significant impact.
Background: Medication non-adherence in pediatric epilepsy remains a significant challenge in Iran, contributing to poor seizure control and increased healthcare costs.Objective: To identify barriers to medication adherence and evaluate the effectiveness of nurse-led interventions in children with epilepsy at Rasool Akram Hospital, Tehran.Methods: A convergent mixed-methods design was employed with 135 children (aged 2–16 years) diagnosed with epilepsy between March 2024 and January 2025. Quantitative data included adherence rates measured by the Pediatric Epilepsy Medication Self-Management Questionnaire (PEMSQ) and seizure frequency. Qualitative data were collected through semi-structured interviews with 28 caregivers . A nurse-led intervention program was implemented over 6 months.Results: Baseline adherence rate was 58.5%. Primary barriers included medication side effects (67.4%), forgetfulness (61.5%), cultural beliefs (43.7%), and financial constraints (38.5%). Post-intervention adherence improved to 81.5% ( < 0.001). Seizure frequency decreased by 42.3%. Qualitative themes revealed stigma, family dynamics, and healthcare system challenges as critical factors.Conclusions: Culturally tailored nursing interventions significantly improve medication adherence in Iranian children with epilepsy. Addressing socio-cultural barriers alongside clinical education is essential for optimal outcomes.
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Mohamadi et al. (2026) studied this question.
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