Primary Intestinal Melanoma Presenting as Intussusception: A Rare Case Report

Primary intestinal melanoma is an extremely rare entity with controversial origin and aggressive clinical course. It constitutes a very small proportion of gastrointestinal malignancies and is often diagnosed late due to nonspecific symptoms. We report a rare case of primary intestinal melanoma presenting as ileocecal intussusception in a young female. A 35-year-old female presented with abdominal pain, vomiting, and melena. Radiological evaluation suggested ileocecal intussusception with a suspicious mass lesion. The patient underwent right hemicolectomy with end ileostomy. Histopathological and immunohistochemical evaluation confirmed invasive melanoma with lymph node metastasis. Despite surgical management, the patient succumbed to the disease 6 months later. This case highlights the rarity, diagnostic difficulty, and poor prognosis of primary intestinal melanoma presenting as intussusception.