What question did this study set out to answer?

This study aims to compare the endocrine outcomes between primary and secondary empty sella over time.

Changes overtime in primary and secondary empty sella: a comparative real-world study

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Longitudinal study compares pituitary function in primary and secondary empty sella, showing differing outcomes.

This study aims to compare the endocrine outcomes between primary and secondary empty sella over time.
Retrospective longitudinal study conducted at a tertiary endocrinology center from 2007 to 2025.
Included adults with diagnosed empty sella categorized into primary or secondary based on clinical history.
Clinical features, comorbidities, and hormonal assessments were collected at baseline and follow-up.
258 participants were analyzed, with primary empty sella (PES) being more prevalent than secondary empty sella (SES) at 61.6% versus 38.4%.
41.1% of patients had at least one pituitary hormone deficiency at baseline, more common in SES (62.6%) than PES (27.7%).
During follow-up, 83.3% of PES patients maintained stable pituitary function, while SES had a significantly higher risk of developing new deficiencies.

Bacchi et al. (2026) studied this question.

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