Integron-mediated gene cassette dynamics in Enterobacterales under selective antibiotic pressure

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to investigate the dynamics of gene cassettes in integrons among Enterobacterales under antibiotic pressure.
Analyzed 494 isolates of Escherichia coli, Klebsiella pneumoniae, and Salmonella Typhi for antibiotic susceptibility.
Performed Sanger sequencing on multidrug-resistant isolates to identify integron regions.
Conducted evolution assays and RT-qPCR to assess gene expression under antibiotic stress.
All E. coli and K. pneumoniae isolates were multidrug-resistant with 94% resistance to ampicillin and 95.2% to ceftazidime.
Integron-positive isolates exhibited higher antibiotic resistance compared to integron-negative ones.
Gene cassette rearrangement in K. pneumoniae was observed from dfrA12-aadA2 to dfrA17-aadA5 after streptomycin treatment.

We only have this paper's title and publication details.

Investigates integron dynamics influencing antibiotic resistance in Enterobacterales, suggesting monitoring could aid treatment.

No takes yet. Share an insight, caveat, or question.

Shetty et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Share