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To define the morphology and distribution of sensory nerve endings from thoracolumbar dorsal root ganglia in the mouse urinary bladder.

Different types of sensory nerve endings in the urinary bladder of mice arising from dorsal root ganglia (DRG) at the thoracolumbar region of vertebral column

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To define the morphology and distribution of sensory nerve endings from thoracolumbar dorsal root ganglia in the mouse urinary bladder.
Employed anterograde neuronal tracing to map sensory endings in bladder
Injected dextran biotin into T12-L3 DRG
Visualized spinal afferent axons and calcitonin gene-related peptide immunoreactivity.
Identified four morphological types of sensory endings, with 79% in sub/urothelium and 21% in detrusor
96% of TL endings were peptidergic (CGRP +)
Distribution of TL nerve endings contrasts sharply with LS innervation patterns.

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Randomized trial maps sensory nerve endings in mouse bladders, indicating anatomical specialization of nerve types.

Spencer et al. (2026) studied this question.

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