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June 10, 2026Open Access

Optimal-Time Mapping in Run-Length Compressed PBWT

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Authors

PBPaola BonizzoniDCDavide CozziYGYounan Gao

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Overview

Randomized trial demonstrates efficient haplotype retrieval in genomic sequences, suggesting improved data structure performance.

Key Points

  • This research aims to enhance the efficiency of the Positional Burrows-Wheeler Transform (PBWT) for genomic sequences by developing a new data structure.
  • Established bounds on the size of runs in the multi-allelic PBWT.
  • Introduced an O(r̃)-word data structure supporting constant-time forward and backward stepping.
  • Designed efficient solutions for haplotype retrieval and prefix search operations.
  • Developed a haplotype retrieval structure achieving O(log log_w h + w) time complexity.
  • Presented a prefix search structure allowing O(m' log log_w σ + occ) query time.
  • Achieved efficient run-length encoding with O(r̃)-word space usage.

Cite This Study

Bonizzoni et al. (2026) studied this question.

synapsesocial.com/papers/6a2900886f82f25be989d091https://doi.org/10.4230/lipics.cpm.2026.22
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