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June 10, 2026Journal of Multimorbidity and ComorbidityOpen Access

Prioritising and ranking methodological uncertainties in the design, conduct, and analysis of trials aiming to improve health outcomes for those living with multiple long-term conditions: A protocol for a modified Delphi study

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Authors

AAAyat AhmadiTehran University of Medical SciencesLZLisong ZhangUniversity of LeicesterNBNatasha BryantUniversity of Leicester

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Implication

Modified Delphi study identifies key uncertainties to improve health outcomes in populations with multiple long-term conditions, indicating a need for better trial design.

Key Points

  • Identify and prioritize methodological uncertainties in trials aimed at improving health outcomes for people with multiple long-term conditions.
  • Four-round modified Delphi study
  • Involves methodologists, trialists, researchers, funders, and lived experience representatives
  • Includes online questionnaires, a lived-experience meeting, and a final consensus meeting
  • Produces a ranked list of methodological uncertainties
  • Findings will guide future research and trial design in multiple long-term conditions
  • Results will be shared through workshops and public engagement activities

Cite This Study

Ahmadi et al. (2026) studied this question.

synapsesocial.com/papers/6a2900b26f82f25be989d282https://doi.org/10.1177/26335565261459136
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