Formulation, Characterization & Optimization of Transdermal Patch of Curcumin

ABSTRACTTransdermal drug delivery systems are defined as self-contained, discrete dosage forms which,when applied to the intact skin, deliver the drug(s), through the skin, at a controlled rate to thesystemic circulation. Transdermal delivery can provide a number of advantages overconventional methodsof drug administration, including enhanced efficacy increased safety,greater convenience and improved patient compliance. By delivering a steady flow of drugs in tothe blood stream over an extended period of time, Transdermal systems can avoid the “peak” and“valley” effect of or injectable therapy and can enable more controlled, effective treatment. Byavoiding first pass metabolism through the gastrointestinal tract and the liver, the therapeuticallyequivalentdosage for the Transdermal delivery of certain compounds can be significantly lessthan the corresponding oral dosage, potentially reducing dosage related side effects. Transdermaltherapeutic systems are designed for controlled drug delivery through the skin in to systemiccirculation maintaining consistent efficacy.