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June 10, 2026Molecular Biology and EvolutionOpen Access

Limited selection on Neanderthal DNA in 30,780 recently admixed genomes with African-like ancestry

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Authors

APAaron PfennigJLJoseph Lachance

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Overview

Randomized trial analyzes Neanderthal DNA effects on evolution in recently admixed genomes, suggesting neutral evolution.

Key Points

  • The study aims to investigate the evolutionary fate of Neanderthal DNA in recently admixed genomes with African-like ancestry.
  • Analyzed 30,780 admixed genomes from the All of Us research program.
  • Assessed Neanderthal DNA contributions and their alignment with expectations based on ancestry proportions.
  • Performed simulations to evaluate potential genome-wide selection of Neanderthal DNA.
  • Observed amounts of Neanderthal DNA matched expected proportions, indicating neutral evolution.
  • Identified genomic regions with unexpected Neanderthal ancestry linked to spermatogenesis and neuronal signaling.
  • Discovered four novel regions with potential hybrid incompatibilities and intrinsic negative selection.

Cite This Study

Pfennig et al. (2026) studied this question.

synapsesocial.com/papers/6a2900d96f82f25be989d544https://doi.org/10.1093/molbev/msag136
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