Phytochemical investigation identifies new iridoid glycosides with hepatocyte protective activity.
In this study, the phytochemical profile of the roots of Nardostachys jatamansi was investigated, leading to the isolation of four iridoid glycosides, including three new compounds: 2”-acetyl-valerosidate (1), 3”-acetyl-valerosidate (2), 10-deoxy-sambucuside F-3”-acetyl (3), and one known compound: 7-deoxy-10-acetyl-loganic acid (4). Their structures were determined by UV, IR, HRESIMS, and NMR data. Screening for anti-hepatocyte injury activity was conducted, and compounds 1 and 3 exhibited significant protective activity.
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Liu et al. (2026) studied this question.
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