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This research aims to determine if fasting 2-hydroxybutyrate can improve dysglycemia detection beyond standard fasting measures.

Enzymatic 2-Hydroxybutyrate Measurement for Dysglycemia Screening Beyond Conventional Fasting Measures

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This research aims to determine if fasting 2-hydroxybutyrate can improve dysglycemia detection beyond standard fasting measures.
Measured fasting 2-hydroxybutyrate using the XpressGT assay in the Biomarkers of Personalized Medicine cohort.
Assessed dysglycemia associations in individuals with fasting plasma glucose <110 mg/dL and HbA1c <39 mmol/mol (5.7%).
Evaluated diagnostic performance using the area under the receiver operating characteristic curve.
Increased levels of 2-hydroxybutyrate were observed from normoglycemia (39.0 µmol/L) to prediabetes (51.9 µmol/L) and type 2 diabetes (57.0 µmol/L).
Achieved a sensitivity of 90% at 39 µmol/L for detecting postprandial dysglycemia, with a negative predictive value of 98.9%.
Each 1-SD increase in 2-hydroxybutyrate correlated with greater dysglycemia risk (odds ratio 2.23; P < 0.001).

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Randomized trial investigates 2-hydroxybutyrate's utility in detecting dysglycemia, suggesting new screening methods.

Strohhofer et al. (2026) studied this question.

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