Key result
A 32-year-old female with primary angiosarcoma of the breast presented with non-specific imaging features and was initially misdiagnosed as a capillary cavernous hemangioma before a second pathology opinion confirmed the malignancy.
Why the study?
Primary angiosarcoma of the breast is a rare, aggressive malignancy that is frequently overlooked or misdiagnosed due to variable and non-specific imaging and pathological features.
Case Report (n=1)
No
Primary angiosarcoma of the breast can present with non-specific imaging features and requires a high index of suspicion and radiology-pathology concordance to avoid misdiagnosis.
Answers are grounded in this paper and cite their sources.
Non-specific breast lesions in young women require radiology-pathology concordance to avoid misdiagnosis; this case report leaves open prospective diagnostic criteria.
Primary angiosarcoma of the breast is a rare (0.04% of all malignant breast tumors) and potentially life-threatening disease. Given its variable and non-specific clinical, radiological and pathological presentation, accurate diagnosis is a challenge. Primary angiosarcoma of the breast predominantly occurs in younger patients and it is often overlooked and misdiagnosed at radiology and pathology. To ensure that this aggressive malignancy is not overlooked, radiologists need to be aware of the fact that such tumors may present with non-specific imaging features. We report a case of a 32-year-old female with primary angiosarcoma of the breast presenting with non-specific imaging features. It was initially interpreted as a capillary cavernous hemangioma at histopathology following an ultrasound-guided biopsy. This eventually turned out to be angiosarcoma after a second histopathology opinion was sought in light of the radiology-pathology discordance.
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Varghese et al. (2019) conducted a case report in Primary Angiosarcoma of the Breast (n=1). Right radical mastectomy with DIEP flap reconstruction was evaluated. A 32-year-old female with primary angiosarcoma of the breast presented with non-specific imaging features and was initially misdiagnosed as a capillary cavernous hemangioma before a second pathology opinion confirmed the malignancy.
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