What is the clinical evidence from this study?

Population: Diet-induced obesity and cardiac arrhythmias (n=42). Intervention: High-fat diet vs. Normal chow (13% kcal/fat). Primary outcome: Duration of arrhythmic events after intravenous epinephrine challenge (p=<0.05).

What does this research mean for the field?

Consumption of a high-fat diet stimulates cardiac sympathetic hyperinnervation even in the absence of overt obesity, but preserved parasympathetic nervous system control protects the heart from arrhythmic events. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 7, 2013AJP Heart and Circulatory PhysiologyOpen Access

Sympathetic cardiac hyperinnervation and atrial autonomic imbalance in diet-induced obesity promote cardiac arrhythmias

Q: What are the key findings of this study?

Obesity-prone rats fed a high-fat diet exhibited a prolonged duration of epinephrine-induced arrhythmias compared to obesity-resistant rats, despite both groups showing cardiac sympathetic hyperinnervation.

Q: What does this research mean for the field?

Consumption of a high-fat diet stimulates cardiac sympathetic hyperinnervation even in the absence of overt obesity, but preserved parasympathetic nervous system control protects the heart from arrhythmic events. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

View Full Paper

Ask AI

Bookmark

Key result

Obesity-prone rats fed a high-fat diet exhibited a prolonged duration of epinephrine-induced arrhythmias compared to obesity-resistant rats, despite both groups showing cardiac sympathetic hyperinnervation.

Why the study?

Does a high-fat diet induce cardiac sympathetic hyperinnervation and increase susceptibility to arrhythmias in male Sprague-Dawley rats?

Structured PICO

Does a high-fat diet induce cardiac sympathetic hyperinnervation and increase susceptibility to arrhythmias in male Sprague-Dawley rats?

Population

42 male Sprague-Dawley rats were fed a high-fat diet or normal chow for 4-6 weeks to investigate the mechanisms linking diet-induced obesity to cardiac arrhythmias.

Intervention

High-fat diet (33% kcal/fat) for 4-6 weeks

Comparator

Normal chow (13% kcal/fat)

Outcome

Arrhythmia duration after intravenous epinephrine challenge, cardiac sympathetic hyperinnervation (TH-immunoreactive area), and atrial neurotransmitter (ACh and NE) content and releasesurrogate

Main Result

p-value: p=<0.05

Diet-induced obesity in rats promotes cardiac sympathetic hyperinnervation and autonomic imbalance, increasing susceptibility to epinephrine-induced arrhythmias.

Limitations

Findings are from an animal model and ex vivo systems, which may not fully translate to humans
The assessment of arrhythmias could not distinguish between atrial and ventricular events
The potential presence of pulmonary hypertension was not ruled out
Assessment of arrhythmias cannot distinguish between atrial and ventricular events
Mechanism of right-sided hyperinnervation requires further investigation

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May link obesity susceptibility to arrhythmia vulnerability via autonomic imbalance; hypothesis-generating in animal models only.

Cite This Study

McCully et al. (2013) studied Diet-induced obesity and cardiac arrhythmias (n=42). High-fat diet vs. Normal chow (13% kcal/fat) was evaluated on Duration of arrhythmic events after intravenous epinephrine challenge (p=<0.05). Obesity-prone rats fed a high-fat diet exhibited a prolonged duration of epinephrine-induced arrhythmias compared to obesity-resistant rats, despite both groups showing cardiac sympathetic hyperinnervation.

synapsesocial.com/papers/6a295226d4e8b5d3999e84c5 https://doi.org/10.1152/ajpheart.00196.2013

View Full Paper

Ask AI

Bookmark

Sympathetic cardiac hyperinnervation and atrial autonomic imbalance in diet-induced obesity promote cardiac arrhythmias

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Sympathetic cardiac hyperinnervation and atrial autonomic imbalance in diet-induced obesity promote cardiac arrhythmias

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider