The hypertriglyceridemic-waist phenotype was associated with an increased risk of coronary artery disease, with an unadjusted hazard ratio of 2.40 in men and 3.84 in women.
Cohort (n=21,787)
Does the hypertriglyceridemic-waist phenotype predict the development of coronary artery disease in apparently healthy individuals?
The hypertriglyceridemic-waist phenotype is a simple, inexpensive marker that identifies individuals with excess intra-abdominal adiposity who are at increased risk for future coronary artery disease.
Hazard Ratio: 2.4 (95% CI 2.02–2.87)
p-value: p=<0.001
BACKGROUND: Screening for increased waist circumference and hypertriglyceridemia (the hypertriglyceridemic-waist phenotype) has been proposed as an inexpensive approach to identify patients with excess intra-abdominal adiposity and associated metabolic abnormalities. We examined the relationship between the hypertriglyceridemic-waist phenotype to the risk of coronary artery disease in apparently healthy individuals. METHODS: A total of 21,787 participants aged 45-79 years were followed for a mean of 9.8 (standard deviation 1.7) years. Coronary artery disease developed in 2109 of them during follow-up. The hypertriglyceridemic-waist phenotype was defined as a waist circumference of 90 cm or more and a triglyceride level of 2.0 mmol/L or more in men, and a waist circumference of 85 cm or more and a triglyceride level of 1.5 mmol/L or more in women. RESULTS: Compared with participants who had a waist circumference and triglyceride level below the threshold, those with the hypertriglyceridemic-waist phenotype had higher blood pressure indices, higher levels of apolipoprotein B and C-reactive protein, lower levels of high-density lipoprotein cholesterol and apolipoprotein A-I, and smaller low-density lipoprotein particles. Among men, those with the hypertriglyceridemic-waist phenotype had an unadjusted hazard ratio for future coronary artery disease of 2.40 (95% confidence interval CI 2.02-2.87) compared with men who did not have the phenotype. Women with the phenotype had an unadjusted hazard ratio of 3.84 (95% CI 3.20-4.62) compared with women who did not have the phenotype. INTERPRETATION: Among participants from a European cohort representative of a contemporary Western population, the hypertriglyceridemic-waist phenotype was associated with a deteriorated cardiometabolic risk profile and an increased risk for coronary artery disease.
Arsenault et al. (Mon,) conducted a cohort in Coronary artery disease (n=21,787). Hypertriglyceridemic-waist phenotype vs. Normal waist circumference and normal triglyceride levels was evaluated on Coronary artery disease (HR 2.40, 95% CI 2.02-2.87, p=<0.001). The hypertriglyceridemic-waist phenotype was associated with an increased risk of coronary artery disease, with an unadjusted hazard ratio of 2.40 in men and 3.84 in women.