Key result
Propionyl-L-carnitine (PLC) and L-carnitine significantly stimulated palmitate oxidation in hypertrophied rat cardiomyocytes, while only PLC significantly increased the ATP/ADP ratio.
Why the study?
Does propionyl-L-carnitine or L-carnitine improve energy metabolism and palmitate oxidation in hypertrophied rat cardiomyocytes?
Population
Hypertrophied quiescent cardiomyocytes isolated from rat hearts 4 weeks after banding of abdominal aorta
Comparison
25 microM propionyl-L-carnitine or L-carnitine vs Untreated hypertrophied cardiomyocytes
Design
Preclinical
Authors
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PLC preferentially raises ATP/ADP in this rat model; hypothesis-generating and requires in vivo validation before any clinical consideration.
Does propionyl-L-carnitine or L-carnitine improve energy metabolism and palmitate oxidation in hypertrophied rat cardiomyocytes?
Propionyl-L-carnitine attenuates early changes in the energy generating system of quiescent cardiomyocytes in pressure overload hypertrophy.
Torielli et al. (1995) studied Cardiac hypertrophy. Propionyl-L-carnitine (PLC) or L-carnitine (LC) vs. Untreated hypertrophied myocytes was evaluated on Palmitate oxidation and ATP/ADP ratio. Propionyl-L-carnitine (PLC) and L-carnitine significantly stimulated palmitate oxidation in hypertrophied rat cardiomyocytes, while only PLC significantly increased the ATP/ADP ratio.
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