Key result
Carotid intima-media thickness independently predicted myocardial infarction, stroke, or death across a wide age range (HR 1.45 per 1 SD increase; 95% CI 1.38-1.52; P<0.0001).
Why the study?
Does carotid intima-media thickness predict the incidence of stroke, myocardial infarction, and death across a wide age range including younger individuals?
Population
5,056 subjects from the Carotid Atherosclerosis Progression Study, including 2,436 younger and 2,620 older…
Design
Cohort
Follow-up
mean 4.2 years
Authors
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IMT may refine risk stratification including in adults <50; extends observational data but should not yet change practice.
Cohort (n=5,056)
Does carotid intima-media thickness predict the incidence of stroke, myocardial infarction, and death across a wide age range including younger individuals?
Hazard Ratio: 1.45 (95% CI 1.38–1.52)
p-value: p=<0.0001
Carotid intima-media thickness is an independent predictor of future vascular events, with a predictive value that is at least as high in younger subjects (<50 years) as in older subjects.
Lorenz et al. (2005) conducted a cohort in Vascular risk (n=5,056). Carotid intima-media thickness (IMT) vs. Lower IMT was evaluated on Myocardial infarction, stroke, or death (HR 1.45, 95% CI 1.38 to 1.52, p=<0.0001). Carotid intima-media thickness independently predicted myocardial infarction, stroke, or death across a wide age range (HR 1.45 per 1 SD increase; 95% CI 1.38-1.52; P<0.0001).
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