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Evaluate the effects of blueberry ellagic acid on hyperuricemia and associated renal injury in mice.

June 11, 2026Journal of Functional FoodsOpen Access

Blueberry ellagic acid attenuates potassium oxonate-induced hyperuricemia and renal injury in mice

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Evaluate the effects of blueberry ellagic acid on hyperuricemia and associated renal injury in mice.
Hyperuricemia model established by potassium oxonate injection (300 mg/kg).
Assessment of renal function, histopathology, inflammatory factors, oxidative stress, and gut microbiota.
Analysis included antioxidants and metabolite composition.
BEA significantly reduced uric acid levels and improved antioxidant capacity.
Renal pathology showed marked improvement in hyperuricemic mice treated with BEA.
Gut microbiota richness increased, leading to beneficial metabolite changes in amino acid and lipid metabolism.

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Implication

Randomized trial demonstrates the effectiveness of blueberry ellagic acid in improving renal function in mice with hyperuricemia, suggesting a new therapeutic approach.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a2a4fa380c8f91e7f39c8d6 https://doi.org/10.1016/j.jff.2026.107378

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Implication

Randomized trial demonstrates the effectiveness of blueberry ellagic acid in improving renal function in mice with hyperuricemia, suggesting a new therapeutic approach.

Blueberry ellagic acid attenuates potassium oxonate-induced hyperuricemia and renal injury in mice

Key Points

Discussion

Implication

Cite This Study

Blueberry ellagic acid attenuates potassium oxonate-induced hyperuricemia and renal injury in mice

Key Points

Discussion

Implication

Cite This Study

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