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This review aims to explore how TGF-β influences the identity and function of tissue-resident macrophages.

June 11, 2026Trends in ImmunologyOpen Access

TGF-β: A master regulator of tissue-resident macrophage identity and function

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Review highlights TGF-β's role in macrophage identity and function, indicating potential for new therapies.

This review aims to explore how TGF-β influences the identity and function of tissue-resident macrophages.
Reviewed existing literature on TGF-β's role in macrophage imprinting and transcriptional programs.
Analyzed the spatial and temporal mechanisms of TGF-β activation in various tissues.
TGF-β is critical in driving macrophage identity within tissue niches, affecting local immune responses.
Regulation of TGF-β activation rather than its levels determines its effects on macrophages.

Döring et al. (2026) studied this question.

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