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Clinical value of kidney immunodeposits and urinary complement activation fragments in IgA nephropathy

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Retrospective analysis identifies immunodeposits and urinary fragments predicting kidney decline in IgAN, suggesting diagnostic utility.

This research aims to determine the clinical significance of kidney immunodeposits and urinary complement fragments in predicting the progression of IgA nephropathy.
Retrospective analysis of 247 IgAN patients from the CureGN cohort
Assessment of immunodeposits by immunofluorescence and electron microscopy
Evaluation of associations between immunodeposits, urinary complemented sC5b9, proteinuria, and kidney outcomes.
Mesangial and endocapillary hypercellularity correlated with IgA and C3 localization by immunofluorescence.
Proteinuria and urinary sC5b9 were linked to detrimental kidney outcomes, including loss of eGFR.
Elevated levels of both proteinuria and urinary sC5b9 indicated a significant interaction affecting progression outcomes.

Royal et al. (2026) studied this question.

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