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June 11, 2026Maternal Health Neonatology and PerinatologyOpen Access

Maternal–neonatal vitamin D gradient at birth in Ilorin, Nigeria: a comparative cross-sectional study

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Authors

OAOjuawo AyodejiOAOjuawo AyodeleAOAdesiyun Omotayo

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Overview

Comparative cross-sectional study measures vitamin D levels at birth, revealing significant insufficiency in neonates.

Key Points

  • To assess the maternal-neonatal vitamin D gradient at birth and its implications for supplementation.
  • Cross-sectional study design involving maternal-neonate pairs in Ilorin, Nigeria.
  • Vitamin D status classified using serum 25(OH)D levels via ELISA.
  • Statistical analyses included paired t-tests, Pearson correlation, and ANOVA.
  • Mean maternal 25(OH)D was 28.54 ng/mL and cord level was 24.85 ng/mL, with an absolute gradient of 3.69 ng/mL (95% CI 1.0-6.4; p = 0.015).
  • Insufficiency affected 52.2% of mothers and 65.2% of neonates, with a significant status discordance (McNemar χ² = 8.97, p = 0.003).
  • Early pre-term neonates showed the highest mean cord 25(OH)D concentration of 29.33 ng/mL, below the sufficiency threshold.

Cite This Study

Ayodeji et al. (2026) studied this question.

synapsesocial.com/papers/6a2a4ff180c8f91e7f39cb65https://doi.org/10.1186/s40748-026-00271-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intergenerational vitamin D deficiency: Correlation between maternal and neonatal levels and the role of supplementation2026
  2. 2Vitamin D status at birth among pregnant women and their newborns in Jordan: a cross-sectional study2026 · 1 citations
  3. 3Vitamin D Metabolites in Mother–Infant Dyads and Associated Clinical Outcomes in a Population of Nigerian Women2024 · 1 citations
  4. 4Maternal Vitamin D Status and Preterm Birth: A Cross-Sectional Comparative Study in Northwestern Nigeria2026
  5. 5A Prospective Cross-Sectional Study on the Vitamin D Status of Neonates and the Impact of Neonates’ Standard Vitamin D Supplementation on Neonatal Morbidities2024 · 4 citations