What question did this study set out to answer?

The aim is to evaluate the current landscape of direct-acting antivirals for influenza and identify challenges.

Effective influenza treatment: a comprehensive review of challenges and advances

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This comprehensive review analyzes antiviral treatments for influenza, highlighting challenges and future directions.

The aim is to evaluate the current landscape of direct-acting antivirals for influenza and identify challenges.
Reviewed existing antiviral drugs including DAAs, neuraminidase inhibitors, and polymerase inhibitors.
Analyzed complexities in drug synthesis, pharmacokinetics, and resistance development.
Provided comparative analyses of WHO-recommended drugs and those approved in various countries.
Identified significant antiviral resistance, particularly with M2 blockers, and to a lesser extent with NA and polymerase inhibitors.
Highlighted suboptimal pharmacokinetic profiles of many existing antiviral treatments as a barrier to effective therapy.
Emphasized the need for balanced strategies in antiviral development to ensure efficacy and global accessibility.

Pomeshikova et al. (2026) studied this question.

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