April 23, 2025Journal of Medicinal Chemistry

Strategic Design and Optimization of Umifenovir Analogues: Balancing Antiviral Efficacy and hERG Toxicity against SARS-CoV-2

View Full Paper

Ask AI

Bookmark

Population

SARS-CoV-2-infected VERO E6 cells

Comparison

Umifenovir analogues vs Umifenovir

Design

Preclinical optimization and in vitro study

Authors

IHIsraful HoqueIndian Institute of Chemical Biology NSNittu SinghInstitute of Microbial Technology UDUddipta Ghosh DastidarIndian Institute of Chemical Biology

Discussion

Member takes

Implication

Optimized Arbidol analogs improve in vitro potency; extends indole scaffold but leaves clinical translation open.

Structured PICO

Population

SARS-CoV-2-infected VERO E6 cells and models for ADME, in vivo PK, and hERG toxicity

Intervention

Umifenovir (Arbidol) analogues (specifically optimized compounds 77, 79, and 81)

Comparator

Arbidol (Umifenovir)

Outcome

Antiviral efficacy (IC50) against SARS-CoV-2 and hERG toxicitysurrogate

Optimization of Umifenovir analogues yielded lead compounds with superior antiviral efficacy against SARS-CoV-2 and eliminated hERG toxicity, supporting their preclinical potential.

Cite This Study

Hoque et al. (2025) studied this question.

synapsesocial.com/papers/6a90d3775d48fdaeb8cae1ce https://doi.org/10.1021/acs.jmedchem.4c03093

View Full Paper

Ask AI

Bookmark

Strategic Design and Optimization of Umifenovir Analogues: Balancing Antiviral Efficacy and hERG Toxicity against SARS-CoV-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Strategic Design and Optimization of Umifenovir Analogues: Balancing Antiviral Efficacy and hERG Toxicity against SARS-CoV-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider