Organocatalytic enantioselective synthesis and derivatizations of bridged N,O-acetal bicyclic scaffolds

Key Points

• The study aims to develop efficient synthetic methods for the enantioselective creation of a key bioactive bicyclic framework.
• Utilized organocatalytic strategies for synthesis of 7-oxa-2-azabicyclo[3.2.1]octane framework.
• Conducted derivatizations for enhanced functionality in bioactive compounds.
• Achieved high enantioselectivity (>90%) in synthesized products.
• Demonstrated successful derivatization, maintaining core structural integrity.