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The aim is to create a prevascularized graft that enhances microvascular formation and tissue perfusion in ischemic diseases.

June 11, 2026AngiogenesisOpen Access

Prevascularized grafts with spatially organized MSC spheroids to accelerate therapeutic angiogenesis in ischemic disease

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The aim is to create a prevascularized graft that enhances microvascular formation and tissue perfusion in ischemic diseases.
Developed a dual-function graft using microvascular pattern and organized MSC spheroids.
Optimized spheroid density and arrangement to boost VEGF secretion and capillary infiltration.
Tested in a murine model of critical limb ischemia.
Achieved a 60% limb salvage rate in the engineered graft group.
Reduced limb loss by approximately 15%, a 4.5-fold improvement over conventional grafts.
Histological analyses confirmed reduced muscle degeneration and improved neovascularization.

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Randomized trial demonstrates improved limb salvage rates with engineered grafts in ischemic conditions, suggesting a novel therapeutic approach.

Son et al. (2026) studied this question.

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Randomized trial demonstrates improved limb salvage rates with engineered grafts in ischemic conditions, suggesting a novel therapeutic approach.