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June 11, 2026BJS OpenOpen Access

Margin status after breast-conserving surgery for breast cancer in the Netherlands from 2009 to 2022

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Authors

JNJoni J. NijveldtBKBas KeizersSSSabine Siesling

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Overview

This observational study reports on margin status in breast-conserving surgery patients, highlighting risk factors for positive margins.

Key Points

  • To evaluate margin status after breast-conserving surgery for breast cancer in the Netherlands from 2009 to 2022, focusing on risk factors.
  • Selected patients from the Netherlands Cancer Registry undergoing breast-conserving surgery for non-metastatic breast cancer from 2009 to 2022.
  • Performed descriptive statistics, trend analyses, and univariate/multivariable analyses to identify risk factors.
  • Developed prediction tools for total and extensively positive margins.
  • A total of 109,475 women were included in the study with a mean tumour-positive margin rate of 10.8%.
  • Risk factors for positive margins included invasive lobular carcinoma and multifocal disease with odds ratios ranging from 1.56 to 2.96.
  • Positive margin probabilities increased from 6.8% (no risk factors) to 49.1% (all four risk factors present).

Cite This Study

Nijveldt et al. (2026) studied this question.

synapsesocial.com/papers/6a2a508980c8f91e7f39d08fhttps://doi.org/10.1093/bjsopen/zrag063
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk factors for positive margin in breast conservation surgery for localized breast cancer.2024
  2. 2The impact of positive surgical margins after cystectomy on oncological outcomes: a nationwide study from the Prospective Bladder Cancer Infrastructure (ProBCI)2026
  3. 3Abstract PO1-22-09: Current margin assessment practice for breast-conserving surgery in China: a single institution audit2024
  4. 4Clinicopathological and imaging factors of surgical margin status and prognosis in breast-conserving therapy2026
  5. 5Prognostic Impact of Surgical Margin Status on Overall Survival of Patients with Early Breast Cancer: A Retrospective Analysis from the Department for Women’s Medicine at Charité – University Hospital Berlin2024 · 1 citations