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June 11, 2026Neonatology

Early Metabolic Alterations are Associated with Intraventricular Hemorrhage and Its Complications in Very Preterm Infants

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Authors

ASAviv SchupperBRBrian ReichmanIZInna Zaslavsky‐Paltiel

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Overview

Observational cohort identifies metabolic changes linked to increased risk of IVH in very preterm infants, suggesting potential for further research.

Key Points

  • This research aims to identify early metabolic alterations in very preterm infants associated with intraventricular hemorrhage and its complications.
  • Population-based observational cohort of 7,313 preterm infants born at 24-32 weeks' gestation.
  • Analytes quantified from dried blood samples within the first 96 hours using tandem mass spectrometry.
  • Multivariable logistic regression analyzed associations between analyte concentrations and IVH.
  • IVH diagnosed in 882 infants, with higher odds of IVH linked to increased methionine (OR 1.50) and proline (OR 1.74) concentrations.
  • Higher free carnitine concentrations associated with lower odds of IVH (OR 0.53).
  • Stronger associations observed in infants with PVHI (n=149) and PHVD (n=152), with p<0.001.

Cite This Study

Schupper et al. (2026) studied this question.

synapsesocial.com/papers/6a2a508980c8f91e7f39d0f6https://doi.org/10.1159/000552886
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Could we detect intraventricular hemorrhage before it happens?2024
  2. 2The Early Hematological Profile and Its Variations: A Useful Tool in the Prediction of Intraventricular Hemorrhage in Extremely Preterm Infants2024 · 1 citations
  3. 3Proceedings of the 15th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc.2024
  4. 4Epigenetic modifications of VEGF, cerebral hypoxia and impaired cerebrovascular autoregulation as early indicators for preterm brain injury2026
  5. 5Antenatal and Perinatal Preventative Strategies for Intraventricular Hemorrhage2026