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June 11, 2026Journal of Cutaneous PathologyOpen Access

Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes

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Authors

IDIsabella DommannGRGaetana RestivoIKIsabel Kolm

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Overview

Retrospective study assessing immune response markers in basal cell carcinoma subtypes, suggesting targeting basosquamous for therapy.

Key Points

  • This research aims to characterize immune response prerequisites associated with PD-L1 in various basal cell carcinoma (BCC) subtypes.
  • Analyzed 77 tumor samples from 4 BCC subtypes by immunohistochemistry
  • Assessed PD-L1 and CD11c + dendritic cells expression in tumor and stroma
  • Quantified immune cell presence by a board-certified pathologist
  • Tumor cells were negative for PD-L1 across all BCC subtypes
  • Basosquamous BCC showed 80% PD-L1 positivity in immune cells
  • HLA class I expression was downregulated compared to the epidermis without significant subtype differences

Cite This Study

Dommann et al. (2026) studied this question.

synapsesocial.com/papers/6a2a508980c8f91e7f39d110https://doi.org/10.1111/cup.70150
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