What question did this study set out to answer?

The aim is to present a rare case of spindle cell/sclerosing rhabdomyosarcoma and discuss diagnostic challenges and treatment strategies.

June 11, 2026Surgical and Experimental PathologyOpen Access

Spindle cell/sclerosing rhabdomyosarcoma of the sphenoid sinus with intracranial and orbital extension: a rare case report with review of literature

View Full Paper

Ask AI

Bookmark

Authors

ASArun Kumar SinghUniversity of Delhi PPPallavi PrasadSanjay Gandhi Post Graduate Institute of Medical Sciences PSPallavi SrivastavaSanjay Gandhi Post Graduate Institute of Medical Sciences

Discussion

Member takes

Implication

Case report reveals challenges in diagnosing and managing a rare aggressive tumor in a young patient, highlighting the importance of molecular testing.

Key Points

The aim is to present a rare case of spindle cell/sclerosing rhabdomyosarcoma and discuss diagnostic challenges and treatment strategies.
Case report of a 17-year-old male with facial swelling and visual blurring, imaging showing a mass in the sphenoid sinus.
Endoscopic endonasal debulking biopsy performed; histopathological examination and immunohistochemistry were conducted.
Next-generation sequencing was utilized to identify genetic mutations associated with the tumor.
Histopathological examination suggested spindle cell/sclerosing rhabdomyosarcoma with immunohistochemistry showing desmin and MyoD1 expression.
Definitive diagnosis confirmed by identifying a MYOD1 p.Leu122Arg mutation through next-generation sequencing.
Multimodal therapy including vincristine, actinomycin D, and proton beam radiotherapy was planned due to unresectable nature.

Cite This Study

Singh et al. (2026) studied this question.

synapsesocial.com/papers/6a2a50b680c8f91e7f39d1b1 https://doi.org/10.1186/s42047-026-00247-2

View Full Paper

Ask AI

Bookmark

Implication

Case report reveals challenges in diagnosing and managing a rare aggressive tumor in a young patient, highlighting the importance of molecular testing.

Spindle cell/sclerosing rhabdomyosarcoma of the sphenoid sinus with intracranial and orbital extension: a rare case report with review of literature

Discussion

Member takes

Implication

Key Points

Cite This Study

Spindle cell/sclerosing rhabdomyosarcoma of the sphenoid sinus with intracranial and orbital extension: a rare case report with review of literature

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider