Micelle-Promoted Aqueous Synthesis of γ-Amino Acid Derivatives via Metal-Free Photoredox Decarboxylative Three-Component Coupling

Gui-Ting Song; Liu Su-ya; Ying Cheng; Shi-You Xue; Wenkai Zong; Shanshan Chen; Lin Zhu; Nian Wang; Jiahong Li; 屈川华

doi:10.1039/d6gc01675h

January 1, 2026Green Chemistry

Micelle-Promoted Aqueous Synthesis of γ-Amino Acid Derivatives via Metal-Free Photoredox Decarboxylative Three-Component Coupling

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Key Points

The aim is to develop a green and efficient method for synthesizing γ-amino acid derivatives.
Aqueous synthesis using visible-light-driven photoredox reactions
Three-component coupling strategy
Utilization of micelles to promote the reaction
Successfully synthesized various γ-amino acid derivatives
Demonstrated significant yields with minimal environmental impact
Showed improved efficiency compared to traditional methods

Implication

Research demonstrates efficient synthesis of γ-amino acids in an eco-friendly manner, indicating a sustainable approach in chemistry.

Abstract

γ-Aminobutyric acid (GABA) analogues are of great value in medicinal chemistry and biomedicine, highlighting the need for efficient, green, and sustainable synthetic strategies. Herein, we report an aqueous visible-light-driven multicomponent...

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Cite This Study

Song et al. (2026) studied this question.

synapsesocial.com/papers/6a2a50e080c8f91e7f39d44d https://doi.org/10.1039/d6gc01675h

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Micelle-Promoted Aqueous Synthesis of γ-Amino Acid Derivatives via Metal-Free Photoredox Decarboxylative Three-Component Coupling

Key Points

Implication

Abstract

Discussion

Cite This Study

Micelle-Promoted Aqueous Synthesis of γ-Amino Acid Derivatives via Metal-Free Photoredox Decarboxylative Three-Component Coupling

Key Points

Implication

Abstract

Discussion

Cite This Study

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