Discovery of a Potent Dual Target CDK8 and Cyclic C PROTAC Degrader for Treatment of Colorectal Cancer

Xingxing Zhang; Qingsong Chen; Cencen Lei; Da Long Jin; Hao Liu; Yumeng Wang; Chenyu zhao; Liping Zhi; Xinhua Liu

doi:10.1039/d6md00281a

January 1, 2026RSC Medicinal Chemistry

Discovery of a Potent Dual Target CDK8 and Cyclic C PROTAC Degrader for Treatment of Colorectal Cancer

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Key Points

The study aims to identify a novel dual-target PROTAC degrader that effectively targets CDK8 and Cyclic C for colorectal cancer treatment.
Developed a PROTAC molecule targeting CDK8 and Cyclic C.
Evaluated its effects on colorectal cancer cell lines through biochemical assays.
Assessed the physiological interactions within signaling pathways.
The PROTAC degrader significantly reduced CDK8 levels in vitro with a corresponding decrease in cancer cell viability.
Demonstrated enhanced degradation of both CDK8 and Cyclic C, leading to altered cellular signaling.
Observed effective anti-tumor activity in preclinical models, highlighting its therapeutic promise.

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Implication

Demonstrates effectiveness of CDK8 and Cyclic C PROTAC degrader in colorectal cancer, indicating strong therapeutic potential.

Abstract

CDK8 exerts important physiological functions, particularly in CRC, by forming intermediate complexes with Cyclic C, MED12, and MED13. In this work, different from the design of traditional single CDK8 protac...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2a50e080c8f91e7f39d4ea https://doi.org/10.1039/d6md00281a

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Discovery of a Potent Dual Target CDK8 and Cyclic C PROTAC Degrader for Treatment of Colorectal Cancer

Key Points

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Implication

Abstract

Discussion

Cite This Study

Discovery of a Potent Dual Target CDK8 and Cyclic C PROTAC Degrader for Treatment of Colorectal Cancer

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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