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June 11, 2026Journal of Medical Internet ResearchOpen Access

Effectiveness of Digital Health Interventions to Improve Self-Care in Patients With Chronic Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Authors

JLJessica LonghiniUniversity of VeronaDPDaniel PedrottiProvincia Autonoma di TrentoFFFederica FoladoriProvincia Autonoma di Trento

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Overview

Systematic review and meta-analysis shows mixed effectiveness of digital interventions for self-care in adults with chronic diseases, indicating areas for improvement.

Key Points

  • This review evaluates the impact of digital health interventions on self-care in adults with chronic diseases.
  • Systematic review of randomized controlled trials (RCTs) from Jan 2013 to Dec 2025.
  • Searched databases included PubMed, CINAHL, Scopus, and PsycINFO for relevant studies.
  • Pooled analyses used random-effects models to compute standardized mean differences (SMDs).
  • In diabetes, overall self-care domains showed little improvement, with low certainty of evidence.
  • In heart failure, improvements in self-care monitoring were noted (SMD=0.49, 95% CI 0.13-0.85; low certainty).
  • Medication adherence showed little to no change (SMD=0.06, 95% CI –0.31 to 0.42; very low certainty).

Cite This Study

Longhini et al. (2026) studied this question.

synapsesocial.com/papers/6a2a50e080c8f91e7f39d51ehttps://doi.org/10.2196/88708
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