Exploiting Singlet Fission in para-Azaquinodimethane Nanoaggregates with High Energy Triplets to Trigger Phototoxic Reactive Oxygen Species

Enrico Sorbelli; Alessio Cesaretti; Martina Alebardi; Roberto Cantoni; Matilde Carloni; Cristina Munzone; Alessandro Grasso; Alessandro Di Michele; Eleonora Calzoni; Cosimo G. Fortuna; Anna Spalletti; Carmela Bonaccorso; Benedetta Carlotti

doi:10.1039/d6sc02556k

January 1, 2026Chemical ScienceOpen Access

Exploiting Singlet Fission in para-Azaquinodimethane Nanoaggregates with High Energy Triplets to Trigger Phototoxic Reactive Oxygen Species

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Key Points

This research aims to explore singlet fission in para-azaquinodimethane derivatives to generate reactive oxygen species for potential applications.
Investigated aggregation-induced singlet fission in water-dispersed nanoaggregates of para-azaquinodimethane derivatives.
Analyzed asymmetrical and symmetrical molecular structures for their efficiency in energy triplet generation.
Assessed the phototoxicity of the produced reactive oxygen species.
Confirmed singlet fission occurs in both asymmetrical and symmetrical pAQM derivatives.
Demonstrated efficient generation of high energy triplet states that trigger reactive oxygen species.
Observed an increased phototoxic effect linked to the presence of these triplet states.

Implication

Investigates singlet fission triggering phototoxic reactive oxygen species in nanoaggregates, suggesting new phototherapeutic applications.

Abstract

In this study, aggregation-induced singlet fission (SF) was unveiled in water-dispersed organic nanoaggregates of push-pull para-azaquinodimethane (pAQM) derivatives exhibiting either asymmetrical (AsOMe and AsNMe2) or symmetrical (TPh and TPhOMe) molecular...

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Cite This Study

Sorbelli et al. (2026) studied this question.

synapsesocial.com/papers/6a2a510680c8f91e7f39d715 https://doi.org/10.1039/d6sc02556k

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Exploiting Singlet Fission in para-Azaquinodimethane Nanoaggregates with High Energy Triplets to Trigger Phototoxic Reactive Oxygen Species

Key Points

Implication

Abstract

Discussion

Cite This Study

Exploiting Singlet Fission in para-Azaquinodimethane Nanoaggregates with High Energy Triplets to Trigger Phototoxic Reactive Oxygen Species

Key Points

Implication

Abstract

Discussion

Cite This Study

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