What question did this study set out to answer?

This study aims to investigate the clinical presentation and diagnostic challenges of cold agglutinin disease (CAD).

June 11, 2026INTERNATIONAL JOURNAL OF CURRENT SCIENCEOpen Access

A Case study on Decoding Cold Agglutinin Disease: Clinical Presentation and Analyzer Interference Resulting from Temperature-Mediated RBC Agglutination

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Case study demonstrates diagnosis challenges of cold agglutinin disease, indicating critical lab interventions are needed.

This study aims to investigate the clinical presentation and diagnostic challenges of cold agglutinin disease (CAD).
Analyzed a 42-year-old male presenting with fever and fatigue; performed complete blood count (CBC) and microscopic evaluation.
Employ temperature-dependent assessments and additional tests like Direct Coombs test and cold agglutinin titers.
Highlighted issues with automated analyzers leading to diagnostic errors in CAD.
Initial CBC resulted in clinically implausible findings, necessitating visual and microscopic evaluations.
RBC clumping confirmed with warming samples to 37°C, leading to normalized parameters.
Diagnosis of CAD established through automated and manual testing, emphasizing analysis flags and manual microscopy.

Ms. Deepti Lodhi (2026) studied this question.

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