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June 11, 2026Current Signal Transduction Therapy

Biomarkers and Stem Cell-based Therapeutics in Alzheimer’s Disease: Recent Advances and Future Directions

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Authors

JKJaved KhanSYShikha Yadav

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Overview

Review summarizes advances in Alzheimer’s disease biomarkers and stem cell therapies, suggesting integrated approaches for precision medicine.

Key Points

  • The review aims to summarize recent advances in Alzheimer's disease pathogenesis and therapeutic strategies.
  • Conducted a comprehensive literature search using PubMed, Scopus, and Web of Science.
  • Included peer-reviewed articles on Alzheimer’s genetics, biomarkers, and stem cell therapies.
  • Critically analyzed preclinical and clinical studies relevant to diagnosis and therapeutic development.
  • Key biomarkers show high diagnostic and prognostic value: CSF amyloid-β1-42, total tau, p-Tau181, neurofilament light chain.
  • Blood-based biomarkers present promising alternatives to traditional CSF diagnostic methods.
  • Stem cell therapies exhibit neuroprotective and regenerative effects in preclinical models of AD.

Cite This Study

Khan et al. (2026) studied this question.

synapsesocial.com/papers/6a2a512e80c8f91e7f39d91fhttps://doi.org/10.2174/0115743624465989260427110348
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recent Advances in Understanding and Treating Alzheimer’s Disease2024
  2. 2From Better Diagnostics to Earlier Treatment: The Rapidly Evolving Alzheimer’s Disease Landscape2025 · 5 citations
  3. 3The Role of Blood-Based Biomarkers in Transforming Alzheimer’s Disease Research and Clinical Management: A Review2025 · 18 citations
  4. 4Pathological mechanisms and treatment progression of Alzheimer’s disease2025 · 69 citations
  5. 5Stem cell therapy offers new hope for the treatment of Alzheimer's disease.2025 · 4 citations