Response Rates and Tolerance to Modified FOLFIRINOX Regimen in Metastatic or Unresectable Gallbladder Cancer: A Prospective Single-arm Interventional Pilot Study

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Key Points

This study aims to evaluate the efficacy, safety, and tolerance of modified FOLFIRINOX in patients with metastatic gallbladder cancer.
Conducted as a single-arm interventional pilot study at a tertiary care center.
Involved patients with metastatic or unresectable gallbladder cancer receiving mFOLFIRINOX treatment.
Evaluated outcomes including safety, response rates, and tolerability.
The study found improved response rates to mFOLFIRINOX compared to historical data on supportive care.
Patients experienced varying degrees of tolerance to the treatment regimen with manageable side effects.
Specific numerical data on overall survival and event rates are yet to be detailed in further analysis.

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Pilot study assesses mFOLFIRINOX safety and efficacy in metastatic gallbladder cancer, suggesting potential for improved outcomes.

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Jain et al. (2026) studied this question.

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