Key result
This review provides an overview of extracellular matrix, specific receptors, and signaling pathways for biomechanical stimulation in cardiac hypertrophy.
This review outlines the complex intracellular and extracellular biomechanical signaling mechanisms underlying cardiac hypertrophy.
May inform future hypertrophy therapies; extends mechanistic insights but leaves clinical translation open.
Biomechanical signaling is a complex interaction of both intracellular and extracellular components. Both passive and active components are involved in the extracellular environment to signal through specific receptors to multiple signaling pathways. This review provides an overview of extracellular matrix, specific receptors, and signaling pathways for biomechanical stimulation in cardiac hypertrophy.
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Sussman et al. (2002) conducted a review in cardiac hypertrophy. This review provides an overview of extracellular matrix, specific receptors, and signaling pathways for biomechanical stimulation in cardiac hypertrophy.
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