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June 11, 2026Organic Letters

Inactivation of P450 Reprograms the Ring Topology of Glycopeptide Antibiotics

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Authors

MMMingzhu MaoXLXingkun LiWQWeiqian Qi

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Overview

Inactivation of P450 reprograms glycopeptide antibiotics' ring structure, suggesting new therapeutic options.

Key Points

  • The study aims to explore how the inactivation of P450 enzymes can change the structure of glycopeptide antibiotics.
  • Point mutation of P450 in the fumamycin biosynthetic gene cluster was performed.
  • The structural changes in glycopeptide antibiotics were analyzed.
  • New derivatives with different cross-link patterns were characterized.
  • Engineered derivatives displayed novel cross-link patterns previously inaccessible.
  • Inactivation of P450 successfully altered the ring topology of glycopeptide antibiotics.
  • Potential for expanding the chemical space of glycopeptide antibiotics was identified.

Cite This Study

Mao et al. (2026) studied this question.

synapsesocial.com/papers/6a2a517c80c8f91e7f39dc29https://doi.org/10.1021/acs.orglett.6c01960
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