Synthesis shows effective production of β-enamino-diesters in varied yields, highlighting a new pathway for carbon frameworks.
In this work, a synthetic protocol for accessing substituted five-membered carbocyclic β-enamino-diesters from isocyanides and donor-acceptor (D-A) cyclobutanes is described. A formal (4 + 1)-cycloaddition furnishes β-enamino-diesters in up to 89% yield from various aliphatic and aromatic isocyanides. In addition, a tandem formal (4 + 1)-cycloaddition followed by decarboxylative tautomerization is demonstrated in a preliminary example, enabling the selective formation of a β-enaminoester.
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Charbonneau et al. (2026) studied this question.
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