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This research aims to explore the relationship between skin thermal dynamics and the dissociation of REM sleep and cataplexy in narcolepsy.

June 11, 2026Open Access

Skin thermal dynamics and hypothalamic thermosensitivity dissociate REM sleep and cataplexy in narcolepsy.

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This research aims to explore the relationship between skin thermal dynamics and the dissociation of REM sleep and cataplexy in narcolepsy.
Examined skin temperature changes preceding cataplexy in narcolepsy patients and Hcrt-KO mice.
Manipulated skin temperature to observe its effects on cataplexy and REM sleep in Hcrt-KO mice.
Utilized fiber photometry and optogenetic manipulation to assess MCH neuron activity related to thermoregulation.
Skin cooling led to increased cataplexy incidence while warming promoted REM sleep.
Cataplexy and REM sleep correlated with MCH neuron activity under constant ambient temperatures (23°C).
Manipulating MCH activity showed that silencing favored cataplexy, whereas activation induced REM sleep.

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Randomized trial reveals distinct effects of skin temperature on cataplexy and REM sleep, suggesting different mechanisms in narcolepsy.

Viberti et al. (2026) studied this question.

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