Performance of Age-Adjusted Whole Genome Sequencing Telomere Length in Idiopathic Pulmonary Fibrosis

John S Kim; B. Receveur; D Zhang; S Ma; Yong Huang; Claire McGroder; Rachel K. Putman; Anna J. Podolanczuk; Jerome I Rotter; S Rich; Kevin R Flaherty; Joyce Lee; Joseph A. Lasky; Ganesh Raghu; S Murray; Catherine Spino; Fernando Betancourt Martínez; Andrea Oh; D A Lynch; S M Humphries; A O Adegunsoye; Justin M. Oldham; Gary M. Hunninghake; Christine Kim Garcia; Margaret Taub; Rasika A. Mathias; Michael H. Cho; R Graham Barr; I Noth; Josyf C. Mychaleckyj; A W Manichaikul; Chad A. Newton

doi:10.1093/ajrccm/aamag259

Key Points

This research aims to assess the effectiveness of age-adjusted whole genome sequencing-estimated telomere length in identifying patients with idiopathic pulmonary fibrosis and its association with survival.
Utilized whole genome sequencing telomere length data from community-dwelling adults and smokers to construct an age-adjusted nomogram (n=9,940).
Generated age-adjusted whole genome sequencing telomere length in idiopathic pulmonary fibrosis cases (n=825) using the nomogram.
Performed diagnostic performance characteristics analysis for identifying telomere-related qualifying variants and survival using receiver operating curves.
28% of idiopathic pulmonary fibrosis patients had abnormally short age-adjusted telomere length < 10th percentile, compared to 5% in community-dwelling adults and 10% in smokers.
Age-adjusted telomere length < 10th percentile demonstrated better sensitivity in discriminating telomere-related qualifying variants with an area under the curve of 0.66.
Age-adjusted telomere length below the 10th percentile was linked to shorter three-year transplant-free survival (HR 1.35, 95% CI 1.05-1.74).

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Implication

Evaluates age-adjusted whole genome sequencing telomere length in adults with idiopathic pulmonary fibrosis, suggesting improved detection of telomere issues.

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Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a2a520a80c8f91e7f39e279 https://doi.org/10.1093/ajrccm/aamag259

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Performance of Age-Adjusted Whole Genome Sequencing Telomere Length in Idiopathic Pulmonary Fibrosis

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Cite This Study

Performance of Age-Adjusted Whole Genome Sequencing Telomere Length in Idiopathic Pulmonary Fibrosis

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No abstract yet

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Cite This Study

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