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June 11, 2026HealthcareOpen Access

Health-Related Quality of Life and Fatigue in Patients with Osteogenesis Imperfecta

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Randomized trial assesses quality of life and fatigue in osteogenesis imperfecta patients, suggesting treatment implications.

To assess health-related quality of life and fatigue in osteogenesis imperfecta patients, comparing them to healthy controls.
Enrolled 27 adults with osteogenesis imperfecta and 27 healthy controls between June 2024 and June 2025.
Assessed fatigue using the Fatigue Severity Scale and health-related quality of life with the SF-36, including Physical and Mental Component Scores.
Evaluated correlations between fatigue, PCS, MCS, and related clinical factors.
Patients with osteogenesis imperfecta types III and IV had significantly lower PCS compared to controls (specific events not provided).
No significant differences in MCS scores or fatigue levels were observed among groups.
Lower PCS scores were linked to lower extremity deformities, fracture history, and orthopedic surgery.

Sarıdaş et al. (2026) studied this question.

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