What question did this study set out to answer?

This research investigates whether direct-acting antivirals impact the pathology and postoperative outcomes in HCV-related HCC patients undergoing liver resection.

June 11, 2026Liver International

Direct Acting Antivirals Before Surgical Resection of HCV Related HCC : Impact on Tumour Pathology and Outcomes

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Authors

GBGiuseppina BrancaccioLink Campus University AVA VitaleUniversity of Padua FRF P RussoUniversity of Padua

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Implication

Randomized trial assesses DAA effects on tumour pathology and survival in HCV-positive HCC, suggesting earlier treatment benefits.

Key Points

This research investigates whether direct-acting antivirals impact the pathology and postoperative outcomes in HCV-related HCC patients undergoing liver resection.
Included 447 patients with HCV-related HCC from 651 total, comparing 107 DAA-treated with 340 No-DAA patients.
Utilized Cox regression to address potential biases with DAA modeled as a time-varying covariate.
Assessed aggressive pathology, severe complications, recurrence-free survival, and overall survival.
DAA-pre patients showed no significant difference in aggressive tumour pathology (58.9% vs. 64.4%, p=0.358).
Severe complications tended to be lower in DAA-pre group (3.9% vs. 11.0%, p=0.073) with shorter hospital stays (6 vs. 7 days, p=0.018).
Improved overall survival was noted with DAA treatment (HR 0.49, 95% CI 0.35-0.68, p<0.001).

Cite This Study

Brancaccio et al. (2026) studied this question.

synapsesocial.com/papers/6a2a528480c8f91e7f39e7ec https://doi.org/10.1111/liv.70738

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Direct Acting Antivirals Before Surgical Resection of HCV Related HCC : Impact on Tumour Pathology and Outcomes

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Implication

Key Points

Cite This Study

Direct Acting Antivirals Before Surgical Resection of HCV Related HCC : Impact on Tumour Pathology and Outcomes

Discussion

Member takes

Implication

Key Points

Cite This Study

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