Demonstrates Zhuyeqing Liquor Extract mitigates neuroinflammation in mice, suggesting its potential as a neuroprotective ingredient.
The aging population highlights the urgency of interventions targeting oxidative stress and neuroinflammation. This study investigated the anti-aging potential of Zhuyeqing Liquor Extract (ZLE) using hydrogen peroxide (H2O2)-induced HT-22 cells and D-galactose-induced aging mice model. Results demonstrated that ZLE exhibited free radical scavenging activity, mitigated neuronal oxidative damage, and suppressed pro-inflammatory cytokine expression. Meanwhile, ZLE alleviated age-related physiological deterioration, improved spatial learning and memory ability, and protected hippocampal neurons in aging mice. Mechanistic analysis revealed that ZLE exerted the bioactivity by activating the SIRT1-Nrf2-HO-1 antioxidant pathway while inhibiting the NF-κB inflammatory pathway. This study suggested that ZLE may have potential as a neuroprotective functional food ingredient, providing a scientific basis for its further development.
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Han et al. (2026) studied this question.
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